The World Leader in Automated Sperm Quality Analyzers with over 3,500 Instruments Sold  

Company Products Support Distributors VideosStudiesContact
- News & Updates
- Manufacturing
- Social Media
- Veterinary Line
- Analyzers
- QwikChecks
- LIS QwikLink
- Validation Kit
- Vet Products
- Recommendations
- Validation
- Quality Control
- Proficiency
- Technical Bulletins
- Procedure Documents
- User Guides
- MSDS Sheets
- Training Videos
- Service Blog
- Studies
- Upgrades
- Batch Releases
- Luvv Letters
- Find a Distributor
- Distributor Support

Rapid - Objective - Standardized Semen Analysis Solutions... Remember, it ALL Started with a Sperm!

RSS  Medical Electronic Systems Service and Support Updates

Updated QwikCheck QC Beads Storage Recommendations

Friday, April 28, 2017

In order to ensure consistent product performance Medical Electronic Systems is now recommending that opened QwikCheck Bead QC Kits be stored @ 2-8°C (36-46°F). The expiration date assumes that QwikCheck beads are stored in their original containers and tightly capped to prevent evaporation. QwikCheck beads are stable and show no loss of expected performance characteristics after transport/storage over a period of 72 hours at the temperature range of -20°C to +37°C (-4°F to +99°F).


Direct Link to this Post: Permalink     

Precision Vs Accuracy Example

Sunday, April 23, 2017

It is important to understand the relationship and difference between Precision and Accuracy.  Both are important, and both showcase different aspects of a Validation or Comparison study. The image below provides a very nice visual representation:

Direct Link to this Post: Permalink     

No Lubricants During Collection

Wednesday, February 15, 2017
It is highly recommended that no lubricants are used during sample collection if the sample is to be run on the SQA platform.  As you can see in the image below, lubricants can leave an oil looking substance in the seminal plasma which may potentially interfere with the automated analysis performed by the SQA-V and SQA-Vision.  Keep it dry and Keep it Accurate!  Remember, it ALL Started with a Sperm!

Direct Link to this Post: Permalink     

The Importance of Semen Sample Liquefaction and Viscosity for Semen Analysis

Thursday, June 16, 2016



In addition to the obvious issues with sample loading in the SQA testing capillary, would concentration readings be higher or lower in a sample which has not fully liquefied?


1.  Running a non-liquefied (or viscous) semen sample will most probably result in inaccurate results for the following reasons:

2.  The sample is poorly represented. In a fully liquefied sample, sperm cells are evenly spread throughout the semen volume and this makes the sample taken for analysis more representative of the entire ejaculate.

3.  Concentration and other semen parameters may vary in both directions in the case of running a viscous sample.

4.  Motility may be lower in viscous samples.

According to the WHO 5th manual, each highly viscous or non-liquefied semen sample should be treated to bring it to normal viscosity prior to testing (WHO 5th ed. manual, p. 13-15;)

Direct Link to this Post: Permalink     

Minimum Sample Volume Requirements for SQA Systems and Dilution Options

Saturday, May 28, 2016
Automated semen assessment using the SQA-V / Vision requires a pre-defined sample volume to be aspirated into the testing capillary in order to generate a full semen analysis report. The volume of the SQA testing capillary is 0.5 ml and this volume provides sufficient statistical representation of the entire ejaculate, resulting in a high level of precision using the automated SQA analyzer.


Based on the required semen sample testing volume of 0.5 mL, it is recommended to fill the entire testing capillary with a semen sample without any dilution if the ejaculate volume is >= 0.5 mL. Sometimes though the ejaculate volume may be less than 0.5 mL. The dilution mode of the SQA-V and Vision can be used in this case as follows: If the semen sample volume is >= 0.3 mL, dilute the sample using the QwikCheck Dilution media two times (1:2 or 1+1). For example, 0.3 mL of semen sample is mixed with 0.3 mL of diluent resulting in a volume of 0.6 mL. This will provide an adequate sample volume to aspirate into the SQA testing capillary and the SQA software automatically compensates for the dilution and will provide a full report, no calculations are required by the operator.


Based on the sample volume, M.E.S. recommends the following approach to testing the sample:
• Semen Volume >= 0.5 mL - No dilution is required
• Semen Volume >= 0.3 mL and < 0.5 mL - Dilution 1:2 (1+1) using the QwikCheck Dilution kit
• Semen Volume < 0.3 mL - Manual assessment [microscope or Vision Manual Mode or Vision Semi-automated Mode (10 µL automated testing + 10 µL manual motility assessment)]


• WHO laboratory manual for the examination and processing of human semen - 5th ed., WHO 2010.
• SQA-V GOLD User Guide Version 2.60 I-Button
• SQA-Vision User Guide Version 104.13.2





Direct Link to this Post: Permalink     

2016 CAP Proficiency Instructions for SQA Systems

Wednesday, April 27, 2016




For All SQA-V and SQA-VISION Systems Version 2.45 and above | UPDATE: April 27th, 2016



The College of American Pathologists ( provides a nationwide proficiency challenge for automated methods of semen analysis.  These results are peer reviewed against other SQA users providing an objective and efficient way to maintain proficiency.  MES recommends this survey as an unbiased appraisal of user proficiency and system performance. 


NOTE: The CAP proficiency material should first be run as Stabilized Sperm in the “Control” mode and re-run in the Test New Patient “Fresh” Mode if a result of 0.0 is reported in Stabilized Sperm Control mode.



  • From the main menu of the SQA-V/SQA-V Gold/Spermalite select: SERVICE > SERVICE DATA.
  • From the V-Sperm computer, navigate to SET UP > SQA-V > SQA-V DEFAULTS and click “CONTINUE”.  You will now see a set-up screen displayed on the PC.
  • On the bottom half of the setup screen, select the “STABILIZED SPERM” option and enter the following for Level 1 and Level 2:    
    • Lot Number = Your Sample Reference # | Target = 50 | Range = 50 | Date = Today’s date.
    • Click “APPLY” and wait a few moments for the information to transfer to the SQA-V.
    • NOTE: Do not forget to change your defaults back to Latex Beads after running your CAP sample!



  1. From the MAIN MENU of the SQA select: RUN CONTROLS > LEVEL 1 and allow system to calibrate.
  2. Mix the sample well by aspirating it in and out 10 times with a transfer pipette.  Avoid bubbles!
  3. Load the SQA-V testing capillary and check CLOSELY for bubbles then wipe the capillary tip clean.
  4. Insert capillary into the testing chamber when prompted to do so.
  5. If a sample result of 0.0 is received, re-run the sample as a FRESH sample.
  6. To Re-Run sample as FRESH, select “Test New Patient” from the main menu and enter the CAP sample number as the Patient ID.
  7. All other entries on the first screen may be skipped.
  8. On the second screen select “FRESH” under sample type and < 1 M/mL for WBC CONC. (all other entry fields may be skipped).
  9. Select YES when asked if sample is sufficient for complete testing > 0.5 M/mL.
  10. Allow system to calibrate and insert the capillary when prompted.
  11. Report the results received.
  12. Repeat Steps 1 – 11 for the second CAP proficiency material level.





  1. From the MAIN MENU of the VISION PC, select SETTINGS > PROIFICIENCY. 
  2. Enter a SAMPLE ID, DATE, and a NOTE (if necessary).
  3. Click SAVE.


  1. Select QC / PROFICIENCY from the main MENU and touch TEST NOW on the desired option.
  2. Mix the sample well by aspirating it in and out 10 times with a transfer pipette.  Avoid bubbles!
  3. Load the SQA-V testing capillary and check CLOSELY for bubbles then wipe the capillary tip clean.
  4. Insert capillary into the testing chamber when prompted to do so.
  5. Report the results received.
  6. Repeat steps 1 through 5 for all samples.



Direct Link to this Post: Permalink     

SQA-VISION Training Outline Now Available

Thursday, March 31, 2016

Click the image below for a screen shot overview of the SQA-VISION instrument.  The document may be used as a training reference tool for MES distributors and end users looking to train new staff members.  Remember, it ALL Started with a Sperm!


Direct Link to this Post: Permalink     

What is the clinical relevance of distinguishing spermatids from WBCs during a semen analysis?

Monday, February 29, 2016

Answer: Leukocytes, predominantly polymorphonuclear leukocytes (PMN, neutrophils), are present in most human ejaculates (Tomlinson et al., 1993; Johanisson et al., 2000). They can sometimes be differentiated from spermatids and spermatocytes in a semen smear stained with the Papanicolaou procedure. Differentiation is based on differences in staining coloration, and on nuclear size and shape (Johanisson et al., 2000). Polymorphonuclear leukocytes can easily be confused morphologically with multinucleated spermatids, but stain a bluish colour, in contrast to the more pinkish colour of spermatids (Johanisson et al., 2000). Nuclear size may also help identification: monocyte nuclei exhibit a wide variation in size, from approximately 7 µm for lymphocytes to over 15 µm for macrophages. These sizes are only guidelines, since degeneration and division affect the size of the nucleus.  There are several other techniques for quantifying the leukocyte population in semen. As peroxidase-positive granulocytes are the predominant form of leukocytes in semen, routine assay of peroxidase activity is useful as an initial screening technique (Wolff, 1995; Johanisson et al., 2000) / (WHO 5th ed. manual, p. 102).

The test can be useful in distinguishing polymorphonuclear leukocytes from multinucleated spermatids, which are peroxidase-free (Johanisson et al., 2000).  (WHO 5th ed. manual, p. 103).

The total number of peroxidase-positive cells in the ejaculate may reflect the severity of an inflammatory condition (Wolff, 1995). This is obtained by multiplying the concentration of peroxidase-positive cells by the volume of the whole ejaculate.  Excessive numbers of leukocytes in the ejaculate (leukocytospermia, pyospermia) may be associated with infection and poor sperm quality.  Leukocyte-dependent damage to spermatozoa depends on the total leukocyte number in the ejaculate and the number of leukocytes relative to the number of spermatozoa.  Leukocytes can impair sperm motility and DNA integrity through an oxidative attack.  (WHO 5th ed. manual, p. 107).

Therefore distinguishing spermatids from WBCs during a semen analysis is of great clinical value. Using the QwikCheck Test Strips for WBC detection allows this differentiation, as this kit is specific for leukocyte (granulocyte) detection.

Direct Link to this Post: Permalink     

Temperature Controls for Storing QwikCheck Dilution Kits After Opening

Monday, August 24, 2015

QwikCheck™ Dilution media is currently labeled “Store at 4°C” after opening. This very specific instruction has been found to be too restrictive and not required.


The QwikCheck™ Dilution kit instructions for storage have been updated to read “Refrigerate after opening 2-8°C” as this is found to be adequate for sustaining the integrity of the media. The new labeling will be seen on the outer box, the bottle label and the product insert for all batches released as of September 1, 2015.


Direct Link to this Post: Permalink     

QwikCheck Semen Test Strips vs. Combur Urine Test Strips for WBC Assessment in Semen

Tuesday, August 18, 2015

For testing pH and WBC in semen, Medical Electronic Systems ( provides FDA cleared QwikCheck™ Test Strips which are specifically labeled for semen sample testing. Customers have requested a comparison of the QwikCheck™Test Strips to urine Test Strips.  Please find a link to the comparison below:


QwikCheck™Semen Test Strips vs. Combur Urine Test Strips


Note: False positive results may occur when using urine test strips (for semen samples with WBC ≥ .5M/ml and ≤ 1M/ml (as the upper range for Urine test strips is .5M/ml.

Direct Link to this Post: Permalink     


Search Tags (Alphabetical):